Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 2 |
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Ligand | BDBM50308844 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_607677 (CHEMBL1071697) |
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IC50 | 25±n/a nM |
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Citation | Combs, AP Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer. J Med Chem53:2333-44 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 2 |
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Name: | Tyrosine-protein phosphatase non-receptor type 2 |
Synonyms: | PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP) |
Type: | Protein |
Mol. Mass.: | 48481.80 |
Organism: | Homo sapiens (Human) |
Description: | P17706 |
Residue: | 415 |
Sequence: | MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVK
LQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES
VKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTW
PDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD
DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA
FDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKAT
TAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
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BDBM50308844 |
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n/a |
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Name | BDBM50308844 |
Synonyms: | 3-Fluoro-N-{1-{(R)-4-[2-(2-methanesulfonyl-phenoxy)-ethyl]-4,5-dihydro-1H-imidazol-2-yl}-2-[3-methyl-4-(1,1,3-trioxo-1lambda*6*-isothiazolidin-5-yl)-phenyl]-ethyl}-benzenesulfonamide | CHEMBL590689 |
Type | Small organic molecule |
Emp. Form. | C30H33FN4O8S3 |
Mol. Mass. | 692.798 |
SMILES | Cc1cc(CC(NS(=O)(=O)c2cccc(F)c2)C2=NC[C@@H](CCOc3ccccc3S(C)(=O)=O)N2)ccc1C1CC(=O)NS1(=O)=O |r,t:18| |
Structure |
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