| Reaction Details |
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 | Report a problem with these data |
| Target | Plasminogen activator inhibitor 1 |
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| Ligand | BDBM50310304 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_607975 (CHEMBL1072391) |
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| IC50 | 343000±n/a nM |
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| Citation |  El-Ayache, NC; Li, SH; Warnock, M; Lawrence, DA; Emal, CD Novel bis-arylsulfonamides and aryl sulfonimides as inactivators of plasminogen activator inhibitor-1 (PAI-1). Bioorg Med Chem Lett20:966-70 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasminogen activator inhibitor 1 |
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| Name: | Plasminogen activator inhibitor 1 |
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| Synonyms: | Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 45064.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05121 |
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| Residue: | 402 |
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| Sequence: | MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
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| BDBM50310304 |
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| n/a |
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| Name | BDBM50310304 |
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| Synonyms: | CHEMBL597510 | N,N'-(ethane-1,2-diyl)bis(N-ethyl-3-hydroxybenzenesulfonamide) |
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| Type | Small organic molecule |
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| Emp. Form. | C18H24N2O6S2 |
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| Mol. Mass. | 428.523 |
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| SMILES | CCN(CCN(CC)S(=O)(=O)c1cccc(O)c1)S(=O)(=O)c1cccc(O)c1 |
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| Structure | 
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