Ki Summary

Reaction Details

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Target

Melanocyte-stimulating hormone receptor

Ligand

BDBM50310324

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_608232 (CHEMBL1072421)

EC50

503±n/a nM

Citation

Ovadia, O; Linde, Y; Haskell-Luevano, C; Dirain, ML; Sheynis, T; Jelinek, R; Gilon, C; Hoffman, A The effect of backbone cyclization on PK/PD properties of bioactive peptide-peptoid hybrids: the melanocortin agonist paradigm. Bioorg Med Chem18:580-9 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocyte-stimulating hormone receptor

Name:

Melanocyte-stimulating hormone receptor

Synonyms:

Type:

PROTEIN

Mol. Mass.:

35238.60

Organism:

Mus musculus

Description:

ChEMBL_1498846

Residue:

315

Sequence:

MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIA
ITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDV
LICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITY
YKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAAT
LTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRS
QELRMTLKEVLLCSW

BDBM50310324

n/a

Name

BDBM50310324

Synonyms:

CHEMBL589515 | Phe-D-Phe-Arg-Trp-NH2

Type

Small organic molecule

Emp. Form.

C35H43N9O4

Mol. Mass.

653.7738

SMILES

N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |r,wU:34.35,wD:1.0,12.12,23.24,(-11.51,1.41,;-10.19,.63,;-10.2,-.91,;-8.88,-1.7,;-8.89,-3.23,;-7.56,-4.02,;-6.22,-3.26,;-6.21,-1.72,;-7.54,-.94,;-8.85,1.38,;-8.83,2.93,;-7.52,.6,;-6.18,1.36,;-6.16,2.9,;-4.82,3.66,;-4.81,5.2,;-3.47,5.96,;-2.14,5.17,;-2.16,3.63,;-3.5,2.88,;-4.85,.58,;-4.87,-.96,;-3.51,1.33,;-2.19,.55,;-2.2,-.99,;-.88,-1.77,;-.89,-3.31,;.44,-4.1,;.43,-5.63,;1.75,-6.42,;-.91,-6.39,;-.84,1.31,;-.82,2.85,;.48,.52,;1.83,1.28,;1.85,2.83,;3.18,3.58,;4.44,2.69,;5.67,3.61,;5.18,5.07,;5.93,6.41,;5.15,7.75,;3.61,7.73,;2.86,6.38,;3.64,5.05,;3.15,.51,;4.5,1.26,;3.14,-1.04,)|

Structure