Reaction Details | |||
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Target | Melanocyte-stimulating hormone receptor | ||
Ligand | BDBM50310317 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_608232 (CHEMBL1072421) | ||
EC50 | 1000±n/a nM | ||
Citation | Ovadia, O; Linde, Y; Haskell-Luevano, C; Dirain, ML; Sheynis, T; Jelinek, R; Gilon, C; Hoffman, A The effect of backbone cyclization on PK/PD properties of bioactive peptide-peptoid hybrids: the melanocortin agonist paradigm. Bioorg Med Chem18:580-9 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Melanocyte-stimulating hormone receptor | |||
Name: | Melanocyte-stimulating hormone receptor | ||
Synonyms: | MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r | ||
Type: | PROTEIN | ||
Mol. Mass.: | 35238.60 | ||
Organism: | Mus musculus | ||
Description: | ChEMBL_1498846 | ||
Residue: | 315 | ||
Sequence: |
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BDBM50310317 | |||
n/a | |||
Name | BDBM50310317 | ||
Synonyms: | 2-((6S,9S,15S)-6-((1H-indol-3-yl)methyl)-13,15-dibenzyl-9-(3-guanidinopropyl)-5,8,11,14,17,21-hexaoxo-1,4,7,10,13,16-hexaazacyclohenicosan-4-yl)acetamide | CHEMBL602654 | ||
Type | Small organic molecule | ||
Emp. Form. | C44H55N11O7 | ||
Mol. Mass. | 849.977 | ||
SMILES | NC(=O)CN1CCNC(=O)CCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N(Cc2ccccc2)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |r,wU:16.16,38.40,wD:49.51,(33.33,.48,;32,-.29,;32,-1.83,;30.67,.48,;29.34,-.3,;28,.47,;28,2.01,;26.62,4.37,;25.28,5.13,;25.27,6.67,;23.95,4.35,;22.61,5.12,;21.28,4.34,;21.29,2.8,;22.63,2.04,;19.97,2.02,;19.98,.48,;18.64,1.25,;18.63,2.79,;19.96,3.56,;19.95,5.1,;18.61,5.87,;17.28,5.08,;17.29,3.54,;18.65,-.3,;17.31,.46,;18.66,-1.84,;17.33,-2.61,;15.99,-1.85,;15.99,-.31,;14.66,.46,;13.33,-.32,;13.33,-1.87,;14.67,-2.63,;20,-2.62,;21.34,-1.85,;21.34,-.31,;22.67,-2.62,;24.01,-1.85,;24.01,-3.39,;22.67,-4.16,;22.67,-5.7,;21.34,-6.47,;21.34,-8.01,;20.01,-8.78,;22.67,-8.78,;25.34,-2.62,;25.34,-4.16,;26.67,-1.85,;28,-2.62,;28,-4.16,;29.34,-4.93,;30.57,-4,;31.84,-4.87,;31.39,-6.35,;32.19,-7.66,;31.45,-9,;29.91,-9.03,;29.11,-7.72,;29.86,-6.37,;29.34,-1.84,;30.68,-2.6,)| | ||
Structure |