| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A2b |
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| Ligand | BDBM50310909 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_622829 (CHEMBL1105839) |
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| IC50 | 17±n/a nM |
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| Citation |  Bedford, ST; Benwell, KR; Brooks, T; Chen, I; Comer, M; Dugdale, S; Haymes, T; Jordan, AM; Kennett, GA; Knight, AR; Klenke, B; LeStrat, L; Merrett, A; Misra, A; Lightowler, S; Padfield, A; Poullennec, K; Reece, M; Simmonite, H; Wong, M; Yule, IA Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor. Bioorg Med Chem Lett19:5945-9 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A2b |
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| Name: | Adenosine receptor A2b |
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| Synonyms: | AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 36341.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 332 |
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| Sequence: | MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFA
IPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGT
RARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMS
YMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIV
GIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT
FHKIISRYLLCQADVKSGNGQAGVQPALGVGL
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| BDBM50310909 |
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| n/a |
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| Name | BDBM50310909 |
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| Synonyms: | (5-methylthiophen-2-yl)(2-(1-(pyridin-3-yl)ethylamino)thieno[3,2-d]pyrimidin-4-yl)methanone | CHEMBL1079115 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16N4OS2 |
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| Mol. Mass. | 380.487 |
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| SMILES | CC(Nc1nc(C(=O)c2ccc(C)s2)c2sccc2n1)c1cccnc1 |
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| Structure | 
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