| Reaction Details |
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 | Report a problem with these data |
| Target | 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 |
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| Ligand | BDBM50311132 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_619853 (CHEMBL1106730) |
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| IC50 | 195±n/a nM |
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| Citation |  Bellavance, E; Luu-The, V; Poirier, D Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. J Med Chem52:7488-502 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 |
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| Name: | 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 |
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| Synonyms: | 17HSD7 | 3-keto-steroid reductase | DHB7_HUMAN | HSD17B7 | SDR37C1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 38212.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_619853 |
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| Residue: | 341 |
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| Sequence: | MRKVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAEAVCAALLASHPTAEVTIV
QVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLFSRKVIHMFSTA
EGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRSARKSNFS
LEDFQHSKGKEPYSSSKYATDLLSVALNRNFNQQGLYSNVACPGTALTNLTYGILPPFIW
TLLMPAILLLRFFANAFTLTPYNGTEALVWLFHQKPESLNPLIKYLSATTGFGRNYIMTQ
KMDLDEDTAEKFYQKLLELEKHIRVTIQKTDNQARLSGSCL
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| BDBM50311132 |
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| n/a |
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| Name | BDBM50311132 |
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| Synonyms: | 17beta-[(N-Decyl)formamido]-4-methyl-4-aza-5alpha-androstan-3-one | CHEMBL1079512 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H52N2O2 |
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| Mol. Mass. | 472.7461 |
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| SMILES | CCCCCCCCCCN(C=O)C1CC[C@H]2[C@@H]3CC[C@H]4N(C)C(=O)CC[C@]4(C)[C@H]3CC[C@]12C |r| |
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| Structure | 
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