Ki Summary

Reaction Details

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Target

Mu-type opioid receptor

Ligand

BDBM50311482

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_622958 (CHEMBL1112210)

113±n/a nM

Citation

Palin, R; Clark, JK; Evans, L; Feilden, H; Fletcher, D; Hamilton, NM; Houghton, AK; Jones, PS; McArthur, D; Montgomery, B; Ratcliffe, PD; Smith, AR; Sutherland, A; Weston, MA; Wishart, G Rapid access towards follow-up NOP receptor agonists using a knowledge based approach. Bioorg Med Chem Lett19:6441-6 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Mu-type opioid receptor

Name:

Mu-type opioid receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

44789.51

Organism:

Homo sapiens (Human)

Description:

P35372

Residue:

400

Sequence:

MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP

BDBM50311482

n/a

Name

BDBM50311482

Synonyms:

2-(1'-(4-tert-butylcyclohexyl)-2-oxospiro[benzo[d][1,3]oxazine-4,4'-piperidine]-1(2H)-yl)-N-methylacetamide | CHEMBL1079418

Type

Small organic molecule

Emp. Form.

C25H37N3O3

Mol. Mass.

427.5796

SMILES

CNC(=O)CN1C(=O)OC2(CCN(CC2)C2CCC(CC2)C(C)(C)C)c2ccccc12 |(6.46,-42.43,;5.12,-41.66,;3.79,-42.42,;3.78,-43.96,;2.46,-41.65,;1.12,-42.42,;-.2,-41.65,;-.2,-40.11,;-1.52,-42.41,;-1.53,-43.94,;-2.87,-43.17,;-4.2,-43.94,;-4.2,-45.48,;-2.86,-46.25,;-1.52,-45.48,;-5.53,-46.25,;-6.88,-45.47,;-8.21,-46.24,;-8.21,-47.78,;-6.88,-48.55,;-5.54,-47.79,;-9.54,-48.54,;-10.87,-47.77,;-9.54,-50.08,;-9.94,-47.06,;-.2,-44.7,;-.21,-46.24,;1.13,-47.01,;2.46,-46.24,;2.46,-44.69,;1.12,-43.94,)|

Structure