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TargetNociceptin receptor
LigandBDBM50311508
Substrate/Competitorn/a
Meas. Tech.ChEMBL_622957
Ki 5.5±n/a nM
Citation Palin RClark JKEvans LFeilden HFletcher DHamilton NMHoughton AKJones PSMcArthur DMontgomery BRatcliffe PDSmith ARSutherland AWeston MAWishart G Rapid access towards follow-up NOP receptor agonists using a knowledge based approach. Bioorg Med Chem Lett 19:6441-6 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Nociceptin receptor
Name:Nociceptin receptor
Synonyms:KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OPIATE ORL-1 | OPRL1 protein | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40702.87
Organism:Homo sapiens (Human)
Description:P41146
Residue:370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA
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BDBM50311508
n/a
NameBDBM50311508
Synonyms:2-(3-(1-(4-tert-butylcyclohexyl)piperidin-4-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-N-methylacetamide | CHEMBL1087658
TypeSmall organic molecule
Emp. Form.C25H38N4O2
Mol. Mass.426.5948
SMILESCNC(=O)Cn1c2ccccc2n(C2CCN(CC2)C2CCC(CC2)C(C)(C)C)c1=O |(11.59,-20.2,;10.05,-20.19,;9.27,-21.51,;10.63,-22.22,;7.73,-21.5,;6.95,-22.83,;5.48,-23.3,;4.15,-22.54,;2.82,-23.31,;2.82,-24.85,;4.15,-25.63,;5.49,-24.85,;6.95,-25.32,;7.73,-26.65,;6.95,-27.98,;7.72,-29.31,;9.26,-29.32,;10.03,-27.98,;9.26,-26.64,;10.02,-30.65,;9.25,-31.97,;10.01,-33.3,;11.55,-33.31,;12.32,-31.98,;11.56,-30.64,;12.31,-34.65,;11.53,-35.98,;13.85,-34.66,;10.82,-35.04,;7.86,-24.07,;9.4,-24.07,)|
Structure
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