| Reaction Details |
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 | Report a problem with these data |
| Target | Sonic hedgehog protein |
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| Ligand | BDBM50311517 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_617885 (CHEMBL1101550) |
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| Kd | >50000±n/a nM |
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| Citation |  Peng, LF; Stanton, BZ; Maloof, N; Wang, X; Schreiber, SL Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog. Bioorg Med Chem Lett19:6319-25 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sonic hedgehog protein |
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| Name: | Sonic hedgehog protein |
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| Synonyms: | SHH | SHH_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49616.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1363190 |
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| Residue: | 462 |
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| Sequence: | MLLLARCLLLVLVSSLLVCSGLACGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASG
RYEGKISRNSERFKELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGV
KLRVTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAH
IHCSVKAENSVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLT
FLDRDDGAKKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGPPSGGALG
PRALFASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVL
ASCYAVIEEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRVALTAPGA
ADAPGAGATAGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS
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| BDBM50311517 |
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| n/a |
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| Name | BDBM50311517 |
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| Synonyms: | (R,E)-N-(4-chlorobenzyl)-2-(5,12-dioxo-1-oxa-4-azacyclododec-8-en-6-yl)acetamide | CHEMBL1080988 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23ClN2O4 |
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| Mol. Mass. | 378.85 |
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| SMILES | Clc1ccc(CNC(=O)C[C@H]2C\C=C\CCC(=O)OCCNC2=O)cc1 |r,t:12| |
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| Structure | 
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