| Reaction Details |
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 | Report a problem with these data |
| Target | Non-lysosomal glucosylceramidase |
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| Ligand | BDBM50312527 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_617534 (CHEMBL1099884) |
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| IC50 | <1±n/a nM |
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| Citation |  Wennekes, T; Meijer, AJ; Groen, AK; Boot, RG; Groener, JE; van Eijk, M; Ottenhoff, R; Bijl, N; Ghauharali, K; Song, H; O'Shea, TJ; Liu, H; Yew, N; Copeland, D; van den Berg, RJ; van der Marel, GA; Overkleeft, HS; Aerts, JM Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. J Med Chem53:689-98 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Non-lysosomal glucosylceramidase |
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| Name: | Non-lysosomal glucosylceramidase |
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| Synonyms: | Beta-glucosidase | GBA2 | GBA2_HUMAN | KIAA1605 | SPG46 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 104639.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1435476 |
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| Residue: | 927 |
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| Sequence: | MGTQDPGNMGTGVPASEQISCAKEDPQVYCPEETGGTKDVQVTDCKSPEDSRPPKETDCC
NPEDSGQLMVSYEGKAMGYQVPPFGWRICLAHEFTEKRKPFQANNVSLSNMIKHIGMGLR
YLQWWYRKTHVEKKTPFIDMINSVPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMY
QHRTVIADQFTVCLRREGQTVYQQVLSLERPSVLRSWNWGLCGYFAFYHALYPRAWTVYQ
LPGQNVTLTCRQITPILPHDYQDSSLPVGVFVWDVENEGDEALDVSIMFSMRNGLGGGDD
APGGLWNEPFCLERSGETVRGLLLHHPTLPNPYTMAVAARVTAATTVTHITAFDPDSTGQ
QVWQDLLQDGQLDSPTGQSTPTQKGVGIAGAVCVSSKLRPRGQCRLEFSLAWDMPRIMFG
AKGQVHYRRYTRFFGQDGDAAPALSHYALCRYAEWEERISAWQSPVLDDRSLPAWYKSAL
FNELYFLADGGTVWLEVLEDSLPEELGRNMCHLRPTLRDYGRFGYLEGQEYRMYNTYDVH
FYASFALIMLWPKLELSLQYDMALATLREDLTRRRYLMSGVMAPVKRRNVIPHDIGDPDD
EPWLRVNAYLIHDTADWKDLNLKFVLQVYRDYYLTGDQNFLKDMWPVCLAVMESEMKFDK
DHDGLIENGGYADQTYDGWVTTGPSAYCGGLWLAAVAVMVQMAALCGAQDIQDKFSSILS
RGQEAYERLLWNGRYYNYDSSSRPQSRSVMSDQCAGQWFLKACGLGEGDTEVFPTQHVVR
ALQTIFELNVQAFAGGAMGAVNGMQPHGVPDKSSVQSDEVWVGVVYGLAATMIQEGLTWE
GFQTAEGCYRTVWERLGLAFQTPEAYCQQRVFRSLAYMRPLSIWAMQLALQQQQHKKASW
PKVKQGTGLRTGPMFGPKEAMANLSPE
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| BDBM50312527 |
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| n/a |
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| Name | BDBM50312527 |
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| Synonyms: | CHEMBL1086996 | N-[5-(Adamantan-1-yl-methoxy)-pentyl]-L-ido-1-deoxynojirimycin |
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| Type | Small organic molecule |
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| Emp. Form. | C22H39NO5 |
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| Mol. Mass. | 397.5488 |
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| SMILES | OC[C@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCOCC12CC3CC(CC(C3)C1)C2 |r,TLB:21:22:20.25.19:26,THB:21:20:22.23.27:26,23:22:19:25.24.26,23:24:21.22.27:19| |
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| Structure | 
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