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TargetSialidase-2
LigandBDBM50312648
Substrate/Competitorn/a
Meas. Tech.ChEMBL_617801 (CHEMBL1100507)
IC50 890000±n/a nM
Citation Arioka, S; Sakagami, M; Uematsu, R; Yamaguchi, H; Togame, H; Takemoto, H; Hinou, H; Nishimura, S Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase. Bioorg Med Chem18:1633-40 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sialidase-2
Name:Sialidase-2
Synonyms:Cytosolic sialidase | N-acetyl-alpha-neuraminidase 2 | NEU2 | NEUR2_HUMAN | Sialidase 2 | Sialidase-2
Type:PROTEIN
Mol. Mass.:42256.20
Organism:Homo sapiens (Human)
Description:ChEMBL_960638
Residue:380
Sequence:
MASLPVLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASKKDEHAELIVLRRGDYD
APTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFFIAIPGQVTEQQQLQTRAN
VTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLHDRARSLVVPAYA
YRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVETGEQRVVTLNARSHL
RARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSVISFPSPRSGPGSPAQWLLYTHPTH
SWQRADLGAYLNPRPPAPEAWSEPVLLAKGSCAYSDLQSMGTGPDGSPLFGCLYEANDYE
EIVFLMFTLKQAFPAEYLPQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50312648
n/a
NameBDBM50312648
Synonyms:(2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-2,3-dihydro-4H-chromen-4-one | (S)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxychroman-4-one | 5,4'-dihydroxy-7-methoxyflavanone | 7-O-methylnaringenin | CHEMBL448297 | Sakuranetin
TypeSmall organic molecule
Emp. Form.C16H14O5
Mol. Mass.286.2794
SMILESCOc1cc(O)c2C(=O)C[C@H](Oc2c1)c1ccc(O)cc1 |r|
Structure
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