| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-adrenergic receptor kinase 2 |
|---|
| Ligand | BDBM3149 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_615172 (CHEMBL1106957) |
|---|
| IC50 | 47±n/a nM |
|---|
| Citation |  Tesmer, JJ; Tesmer, VM; Lodowski, DT; Steinhagen, H; Huber, J Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. J Med Chem53:1867-70 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-adrenergic receptor kinase 2 |
|---|
| Name: | Beta-adrenergic receptor kinase 2 |
|---|
| Synonyms: | ADRBK2 | ARBK2_HUMAN | BARK2 | GRK3 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 79721.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_615172 |
|---|
| Residue: | 688 |
|---|
| Sequence: | MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN
QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC
SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV
ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE
IILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPE
VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE
LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA
DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARK
RAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNL
LTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRR
APKFLNKPRSGTVELPKPSLCHRNSNGL
|
|
|
|---|
| BDBM3149 |
|---|
| n/a |
|---|
| Name | BDBM3149 |
|---|
| Synonyms: | 2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl]oxy}carbonyl)phenyl]carbonyl}-3-hydroxybenzoic acid | Acyclic Balanol Analog (-)-1 | Balanol analog 1 | Balanol, 1 | CHEMBL60254 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H26N2O10 |
|---|
| Mol. Mass. | 550.5134 |
|---|
| SMILES | OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
