| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine phosphorylase |
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| Ligand | BDBM50313094 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_616439 (CHEMBL1100898) |
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| Ki | 17±n/a nM |
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| Citation |  Jain, HV; Rasheed, R; Kalman, TI The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism. Bioorg Med Chem Lett20:1648-51 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine phosphorylase |
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| Name: | Thymidine phosphorylase |
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| Synonyms: | ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 49948.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319). |
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| Residue: | 482 |
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| Sequence: | MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ
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| BDBM50313094 |
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| n/a |
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| Name | BDBM50313094 |
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| Synonyms: | 5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil | CHEMBL1080896 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H8FN5O2 |
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| Mol. Mass. | 225.1798 |
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| SMILES | Nc1nccn1Cc1[nH]c(=O)[nH]c(=O)c1F |
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| Structure | 
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