| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase NLK |
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| Ligand | BDBM50314070 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_627168 (CHEMBL1111810) |
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| Kd | 170±n/a nM |
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| Citation |  Goldstein, DM; Kuglstatter, A; Lou, Y; Soth, MJ Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. J Med Chem53:2345-53 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase NLK |
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| Name: | Serine/threonine-protein kinase NLK |
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| Synonyms: | LAK1 | NLK | NLK_HUMAN | Serine/threonine protein kinase NLK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58306.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774580 |
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| Residue: | 527 |
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| Sequence: | MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLHHHHHPQHHLHPGSAAA
VHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQAPGPAAAAPAQVQAAAAAT
VKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCK
RVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDH
VKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEELDESRHMTQE
VVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTP
SLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKD
ALAHPYLDEGRLRYHTCMCKCCFSTSTGRVYTSDFEPVTNPKFDDTFEKNLSSVRQVKEI
IHQFILEQQKGNRVPLCINPQSAAFKSFISSTVAQPSEMPPSPLVWE
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| BDBM50314070 |
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| n/a |
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| Name | BDBM50314070 |
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| Synonyms: | 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxyethyl)propyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one | CHEMBL1090089 | pamapimod |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20F2N4O4 |
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| Mol. Mass. | 406.3833 |
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| SMILES | Cn1c2nc(NC(CCO)CCO)ncc2cc(Oc2ccc(F)cc2F)c1=O |
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| Structure | 
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