| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 11 |
|---|
| Ligand | BDBM50266947 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_627164 (CHEMBL1111806) |
|---|
| Kd | 15±n/a nM |
|---|
| Citation |  Goldstein, DM; Kuglstatter, A; Lou, Y; Soth, MJ Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. J Med Chem53:2345-53 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase 11 |
|---|
| Name: | Mitogen-activated protein kinase 11 |
|---|
| Synonyms: | MAP kinase p38 | MAPK11 | MK11_HUMAN | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | PRKM11 | SAPK2 | SAPK2B | Stress-activated protein kinase 2 | p38 MAP kinase alpha/beta | p38-2 | p38-beta | p38b |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 41351.73 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_20128774 |
|---|
| Residue: | 364 |
|---|
| Sequence: | MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL
EIEQ
|
|
|
|---|
| BDBM50266947 |
|---|
| n/a |
|---|
| Name | BDBM50266947 |
|---|
| Synonyms: | 2-(6-chloro-5-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazine-1-carbonyl)-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide | 2-(6-chloro-5-{[(2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazin-1-yl]carbonyl}-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide | CHEMBL514201 | talmapimod |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H30ClFN4O3 |
|---|
| Mol. Mass. | 513.004 |
|---|
| SMILES | C[C@H]1CN([C@H](C)CN1Cc1ccc(F)cc1)C(=O)c1cc2c(cn(C)c2cc1Cl)C(=O)C(=O)N(C)C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
