Reaction Details | |||
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Target | IgG receptor FcRn large subunit p51 | ||
Ligand | BDBM50314091 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_627629 (CHEMBL1114459) | ||
IC50 | 18±n/a nM | ||
Citation | McDonnell, KA; Low, SC; Hoehn, T; Donnelly, R; Palmieri, H; Fraley, C; Sakorafas, P; Mezo, AR Synthesis and structure-activity relationships of dimeric peptide antagonists of the human immunoglobulin G-human neonatal Fc receptor (IgG-FcRn) interaction. J Med Chem53:1587-96 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
IgG receptor FcRn large subunit p51 | |||
Name: | IgG receptor FcRn large subunit p51 | ||
Synonyms: | FCGRN_HUMAN | FCGRT | FCRN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 39742.86 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_627631 | ||
Residue: | 365 | ||
Sequence: |
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BDBM50314091 | |||
n/a | |||
Name | BDBM50314091 | ||
Synonyms: | CHEMBL1090279 | N-[(1S)-1-{[(1S)-1-{[(5S,8S,15S,18R,23R,26S,32S,35S,38S)-35-benzyl-18-carbamoyl-8-[(4-hydroxyphenyl)methyl]-32-(1H-imidazol-4-ylmethyl)-4,22,22,25,26-pentamethyl-5-(2-methylpropyl)-3,6,9,10,16,24,27,30,33,36,42-undecaoxo-20,21-dithia-1,4,7,11,17,25,28,31,34,37-decaazatricyclo[36.3.1.0^{11,15}]dotetracontan-23-yl]carbamoyl}-2-phenylethyl]carbamoyl}-4-carbamimidamidobutyl]-N'-{2-[({[(1S)-1-{[(1S)-1-{[(5S,8S,15S,18R,23R,26S,32S,35S,38S)-35-benzyl-18-carbamoyl-8-[(4-hydroxyphenyl)methyl]-32-(1H-imi | ||
Type | Small organic molecule | ||
Emp. Form. | C155H214N40O33S4 | ||
Mol. Mass. | 3293.866 | ||
SMILES | CC(C)C[C@@H]1N(C)C(=O)CN2CCC[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)CNC(=O)[C@H](C)N(C)C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CCC(=O)NCCN(C)CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H]3C(=O)N(C)[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc4cnc[nH]4)C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@H]4CCCN(CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](Cc5ccc(O)cc5)C(=O)C(=O)N5CCC[C@H]5C(=O)N[C@@H](CSSC3(C)C)C(N)=O)C4=O)C(C)(C)SSC[C@H](NC(=O)[C@@H]3CCCN3C(=O)C(=O)[C@H](Cc3ccc(O)cc3)NC1=O)C(N)=O)C2=O |r| | ||
Structure |