Ki Summary

Reaction Details

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Target

IgG receptor FcRn large subunit p51

Ligand

BDBM50314083

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_627629 (CHEMBL1114459)

IC50

1900±n/a nM

Citation

McDonnell, KA; Low, SC; Hoehn, T; Donnelly, R; Palmieri, H; Fraley, C; Sakorafas, P; Mezo, AR Synthesis and structure-activity relationships of dimeric peptide antagonists of the human immunoglobulin G-human neonatal Fc receptor (IgG-FcRn) interaction. J Med Chem53:1587-96 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

IgG receptor FcRn large subunit p51

Name:

IgG receptor FcRn large subunit p51

Synonyms:

FCGRN_HUMAN | FCGRT | FCRN

Type:

PROTEIN

Mol. Mass.:

39742.86

Organism:

Homo sapiens (Human)

Description:

ChEMBL_627631

Residue:

365

Sequence:

MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLS
YNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCE
LGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLF
SCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGL
AAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLV
VGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNV
IPATA

BDBM50314083

n/a

Name

BDBM50314083

Synonyms:

(3S,11S,14S,20S,23R,32S,35S,41aS)-20-((1H-imidazol-4-yl)methyl)-11-((S)-2-((S)-2-acetamido-5-guanidinopentanamido)-3-phenylpropanamido)-23-benzyl-35-(4-hydroxybenzyl)-14-((R)-1-hydroxyethyl)-32-isobutyl-28,31-dimethyl-1,9,12,15,18,21,24,27,30,33,36,37-dodecaoxotetracontahydro-1H-pyrrolo[1,2-z][1,4,7,10,13,16,19,22,26,29,35]undecaazacyclononatriacontine-3-carboxamide | CHEMBL1089951

Type

Small organic molecule

Emp. Form.

C75H104N20O18

Mol. Mass.

1573.7515

SMILES

CC(C)C[C@@H]1N(C)C(=O)CN(C)C(=O)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)[C@@H](C)O |r|

Structure