Reaction Details |
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Target | 5-hydroxytryptamine receptor 2B |
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Ligand | BDBM50314625 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_625152 (CHEMBL1115173) |
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Ki | 2400±n/a nM |
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Citation | Liu, KK; Lefker, BA; Dombroski, MA; Chiang, P; Cornelius, P; Patterson, TA; Zeng, Y; Santucci, S; Tomlinson, E; Gibbons, CP; Marala, R; Brown, JA; Kong, JX; Lee, E; Werner, W; Wenzel, Z; Giragossian, C; Chen, H; Coffey, SB Orally active and brain permeable proline amides as highly selective 5HT2c agonists for the treatment of obesity. Bioorg Med Chem Lett20:2365-9 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 2B |
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Name: | 5-hydroxytryptamine receptor 2B |
Synonyms: | 5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 54312.47 |
Organism: | Homo sapiens (Human) |
Description: | Receptor binding assays were performed using human clone stably expressed in CHO cells. |
Residue: | 481 |
Sequence: | MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
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BDBM50314625 |
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n/a |
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Name | BDBM50314625 |
Synonyms: | (S)-N-(4-(3-fluorophenoxy)benzyl)pyrrolidine-2-carboxamide | CHEMBL1090757 |
Type | Small organic molecule |
Emp. Form. | C18H19FN2O2 |
Mol. Mass. | 314.3541 |
SMILES | Fc1cccc(Oc2ccc(CNC(=O)[C@@H]3CCCN3)cc2)c1 |r| |
Structure |
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