Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM50314759 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_626172 (CHEMBL1117029) |
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Ki | 0.458±n/a nM |
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Citation | Ivachtchenko, AV; Dmitriev, DE; Golovina, ES; Dubrovskaya, ES; Kadieva, MG; Koryakova, AG; Kysil, VM; Mitkin, OD; Tkachenko, SE; Okun, IM; Vorobiov, AA Synthesis of cycloalkane-annelated 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines and their evaluation as 5-HT6 receptor antagonists. Bioorg Med Chem Lett20:2133-6 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50314759 |
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n/a |
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Name | BDBM50314759 |
Synonyms: | 2-(methylthio)-3-(phenylsulfonyl)-7,8-dihydro-6H-cyclopenta[e]pyrazolo[1,5-a]pyrimidine | CHEMBL1091206 | US8629154, 1.1(1) |
Type | Small organic molecule |
Emp. Form. | C16H15N3O2S2 |
Mol. Mass. | 345.439 |
SMILES | CSc1nn2c3CCCc3cnc2c1S(=O)(=O)c1ccccc1 |
Structure |
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