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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Carbonic anhydrase | ||
| Ligand | BDBM25905 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_626038 (CHEMBL1106166) | ||
| Ki | 78±n/a nM | ||
| Citation |  Güzel, O; Maresca, A; Hall, RA; Scozzafava, A; Mastrolorenzo, A; Mühlschlegel, FA; Supuran, CT Carbonic anhydrase inhibitors. The beta-carbonic anhydrases from the fungal pathogens Cryptococcus neoformans and Candida albicans are strongly inhibited by substituted-phenyl-1H-indole-5-sulfonamides. Bioorg Med Chem Lett20:2508-11 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Carbonic anhydrase | |||
| Name: | Carbonic anhydrase | ||
| Synonyms: | CAN_CANAL | NCE103 | beta-Carbonic Anhydrase | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 31587.59 | ||
| Organism: | Candida albicans (Yeast) | ||
| Description: | n/a | ||
| Residue: | 281 | ||
| Sequence: |
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| BDBM25905 | |||
| n/a | |||
| Name | BDBM25905 | ||
| Synonyms: | 2-(hydrazinecarbonyl)-3-(2-methylphenyl)-1H-indole-5-sulfonamide | BMC173212 Compound 2a | indole sulfonamide, 8a | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H16N4O3S | ||
| Mol. Mass. | 344.388 | ||
| SMILES | Cc1ccccc1-c1c([nH]c2ccc(cc12)S(N)(=O)=O)C(=O)NN |(-3.28,7.1,;-1.8,7.52,;-1.42,9.01,;.06,9.43,;1.17,8.36,;.79,6.86,;-.69,6.44,;-1.17,4.98,;-.26,3.73,;-1.17,2.49,;-2.63,2.96,;-3.97,2.19,;-5.3,2.96,;-5.3,4.5,;-3.97,5.27,;-2.63,4.5,;-6.63,5.27,;-7.97,6.04,;-5.86,6.61,;-7.4,3.94,;1.28,3.73,;2.05,2.4,;2.05,5.07,;3.59,5.07,)| | ||
| Structure | 
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