Reaction Details |
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Target | Carbonic anhydrase |
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Ligand | BDBM50258715 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_626038 (CHEMBL1106166) |
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Ki | 64±n/a nM |
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Citation | Güzel, O; Maresca, A; Hall, RA; Scozzafava, A; Mastrolorenzo, A; Mühlschlegel, FA; Supuran, CT Carbonic anhydrase inhibitors. The beta-carbonic anhydrases from the fungal pathogens Cryptococcus neoformans and Candida albicans are strongly inhibited by substituted-phenyl-1H-indole-5-sulfonamides. Bioorg Med Chem Lett20:2508-11 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase |
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Name: | Carbonic anhydrase |
Synonyms: | CAN_CANAL | NCE103 | beta-Carbonic Anhydrase |
Type: | Enzyme |
Mol. Mass.: | 31587.59 |
Organism: | Candida albicans (Yeast) |
Description: | n/a |
Residue: | 281 |
Sequence: | MGRENILKYQLEHDHESDLVTEKDQSLLLDNNNNLNGMNNTIKTHPVRVSSGNHNNFPFT
LSSESTLQDFLNNNKFFVDSIKHNHGNQIFDLNGQGQSPHTLWIGCSDSRAGDQCLATLP
GEIFVHRNIANIVNANDISSQGVIQFAIDVLKVKKIIVCGHTDCGGIWASLSKKKIGGVL
DLWLNPVRHIRAANLKLLEEYNQDPKLKAKKLAELNVISSVTALKRHPSASVALKKNEIE
VWGMLYDVATGYLSQVEIPQDEFEDLFHVHDEHDEEEYNPH
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BDBM50258715 |
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n/a |
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Name | BDBM50258715 |
Synonyms: | 1-({[5-(Aminosulfonyl)-3-(3-bromophenyl)-1H-indol-2-yl]carbonyl}amino)-2,4,6 trimethylpyridinium perchlorate | 2,4,6-trimethyl-1-(5-sulfamoyl-3-m-tolyl-1H-indole-2-carboxamido)pyridinium perchlorate | CHEMBL468945 |
Type | Small organic molecule |
Emp. Form. | C24H25N4O3S |
Mol. Mass. | 449.545 |
SMILES | Cc1cccc(c1)-c1c([nH]c2ccc(cc12)S(N)(=O)=O)C(=O)N[n+]1c(C)cc(C)cc1C |
Structure |
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