| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin F2-alpha receptor |
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| Ligand | BDBM50315467 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_626797 (CHEMBL1107244) |
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| IC50 | >20000±n/a nM |
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| Citation |  Zhou, N; Polozov, AM; O'Connell, M; Burgeson, J; Yu, P; Zeller, W; Zhang, J; Onua, E; Ramirez, J; Palsdottir, GA; Halldorsdottir, GV; Andresson, T; Kiselyov, AS; Gurney, M; Singh, J 1,7-Disubstituted oxyindoles are potent and selective EP(3) receptor antagonists. Bioorg Med Chem Lett20:2658-64 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin F2-alpha receptor |
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| Name: | Prostaglandin F2-alpha receptor |
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| Synonyms: | PF2R_HUMAN | PGF receptor | PGF2 alpha receptor | PGF2-alpha receptor | PTGFR | Prostaglandin F | Prostanoid FP receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40072.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43088 |
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| Residue: | 359 |
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| Sequence: | MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQ
KSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGL
CPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQ
ASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQG
RSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILD
PWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
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| BDBM50315467 |
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| n/a |
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| Name | BDBM50315467 |
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| Synonyms: | CHEMBL1093791 | N-(4-fluorophenylsulfonyl)-3-(3-hydroxy-1-(naphthalen-2-ylmethyl)-2-oxoindolin-7-yl)acrylamide |
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| Type | Small organic molecule |
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| Emp. Form. | C28H21FN2O5S |
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| Mol. Mass. | 516.54 |
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| SMILES | OC1C(=O)N(Cc2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1ccc(F)cc1 |
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| Structure | 
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