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TargetProstaglandin E2 receptor
LigandBDBM50315528
Substrate/Competitorn/a
Meas. Tech.ChEMBL_626787
IC50 0.3±n/a nM
Citation Zhou NPolozov AMO'Connell MBurgeson JYu PZeller WZhang JOnua ERamirez JPalsdottir GAHalldorsdottir GVAndresson TKiselyov ASGurney MSingh J 1,7-Disubstituted oxyindoles are potent and selective EP(3) receptor antagonists. Bioorg Med Chem Lett 20:2658-64 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E2 receptor
Name:Prostaglandin E2 receptor
Synonyms:PGE receptor, EP3 subtype | PGE2-R | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor
Type:Enzyme
Mol. Mass.:43335.03
Organism:Homo sapiens (Human)
Description:P43115
Residue:390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL
TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW
EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG
VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL
ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI
MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQI
RYHTNNYASSSTSLPCQCSSTLMWSDHLER
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  Blast E-value cutoff:
BDBM50315528
n/a
NameBDBM50315528
Synonyms:3-(3-methyl-1-(naphthalen-2-ylmethyl)-2-oxoindolin-7-yl)-N-(2,4,5-trifluorophenylsulfonyl)acrylamide | CHEMBL1090460
TypeSmall organic molecule
Emp. Form.C29H21F3N2O4S
Mol. Mass.550.548
SMILESCC1C(=O)N(Cc2ccc3ccccc3c2)c2c1cccc2\C=C\C(=O)NS(=O)(=O)c1cc(F)c(F)cc1F
Structure
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