| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A3 |
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| Ligand | BDBM50315644 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_623793 (CHEMBL1117076) |
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| Ki | 0.201±n/a nM |
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| Citation |  Cheong, SL; Dolzhenko, A; Kachler, S; Paoletta, S; Federico, S; Cacciari, B; Dolzhenko, A; Klotz, KN; Moro, S; Spalluto, G; Pastorin, G The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition. J Med Chem53:3361-75 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A3 |
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| Name: | Adenosine receptor A3 |
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| Synonyms: | A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 36197.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P0DMS8 |
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| Residue: | 318 |
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| Sequence: | MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA
VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKR
VTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF
SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA
LSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC
VVCHPSDSLDTSIEKNSE
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| BDBM50315644 |
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| n/a |
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| Name | BDBM50315644 |
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| Synonyms: | CHEMBL1091640 | N-[2-(4-Fluorophenyl)-8-methylpyrazolo[4,3-e][1,2,4]triazolo-[1,5-c]pyrimidin-5-yl]phenylacetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16FN7O |
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| Mol. Mass. | 401.3964 |
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| SMILES | Cn1cc2c(n1)nc(NC(=O)Cc1ccccc1)n1nc(nc21)-c1ccc(F)cc1 |
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| Structure | 
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