Reaction Details |
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Target | C-C chemokine receptor type 2 |
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Ligand | BDBM50315995 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_625751 (CHEMBL1104428) |
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IC50 | 4500±n/a nM |
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Citation | Cherney, RJ; Mo, R; Meyer, DT; Voss, ME; Yang, MG; Santella, JB; Duncia, JV; Lo, YC; Yang, G; Miller, PB; Scherle, PA; Zhao, Q; Mandlekar, S; Cvijic, ME; Barrish, JC; Decicco, CP; Carter, PH gamma-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists. Bioorg Med Chem Lett20:2425-30 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-C chemokine receptor type 2 |
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Name: | C-C chemokine receptor type 2 |
Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
Type: | Enzyme |
Mol. Mass.: | 41932.32 |
Organism: | Homo sapiens (Human) |
Description: | P41597 |
Residue: | 374 |
Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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BDBM50315995 |
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n/a |
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Name | BDBM50315995 |
Synonyms: | (+/-)-N-(1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-((4-(methylthio)phenylsulfonyl)methyl)cyclohexyl)-3-methyl-2-oxopyrrolidin-3-yl)-3-(trifluoromethyl)benzamide | CHEMBL1093319 | N-(1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-((4-(methylthio)phenylsulfonyl)methyl)cyclohexyl)-3-methyl-2-oxopyrrolidin-3-yl)-3-(trifluoromethyl)benzamide |
Type | Small organic molecule |
Emp. Form. | C31H40F3N3O4S2 |
Mol. Mass. | 639.792 |
SMILES | CSc1ccc(cc1)S(=O)(=O)C[C@@H]1C[C@@H](CC[C@@H]1N1CCC(C)(NC(=O)c2cccc(c2)C(F)(F)F)C1=O)N(C)C(C)C |r| |
Structure |
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