Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetC-C chemokine receptor type 2
LigandBDBM50315996
Substrate/Competitorn/a
Meas. Tech.ChEMBL_625751 (CHEMBL1104428)
IC50>1000±n/a nM
Citation Cherney, RJ; Mo, R; Meyer, DT; Voss, ME; Yang, MG; Santella, JB; Duncia, JV; Lo, YC; Yang, G; Miller, PB; Scherle, PA; Zhao, Q; Mandlekar, S; Cvijic, ME; Barrish, JC; Decicco, CP; Carter, PH gamma-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists. Bioorg Med Chem Lett20:2425-30 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-C chemokine receptor type 2
Name:C-C chemokine receptor type 2
Synonyms:C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:Enzyme
Mol. Mass.:41932.32
Organism:Homo sapiens (Human)
Description:P41597
Residue:374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50315996
n/a
NameBDBM50315996
Synonyms:CHEMBL1088930 | N-((S)-1-((1S,2R,4R)-4-(isopropyl(methyl)amino)-2-(phenylsulfonylmethyl)cyclohexyl)-4,4-dimethyl-2-oxopyrrolidin-3-yl)-3-(trifluoromethyl)benzamide
TypeSmall organic molecule
Emp. Form.C31H40F3N3O4S
Mol. Mass.607.727
SMILESCC(C)N(C)[C@@H]1CC[C@@H]([C@H](CS(=O)(=O)c2ccccc2)C1)N1CC(C)(C)[C@H](NC(=O)c2cccc(c2)C(F)(F)F)C1=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: