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TargetC-C chemokine receptor type 2
LigandBDBM50315999
Substrate/Competitorn/a
Meas. Tech.ChEMBL_625750 (CHEMBL1104427)
IC50 278±n/a nM
Citation Cherney, RJ; Mo, R; Meyer, DT; Voss, ME; Yang, MG; Santella, JB; Duncia, JV; Lo, YC; Yang, G; Miller, PB; Scherle, PA; Zhao, Q; Mandlekar, S; Cvijic, ME; Barrish, JC; Decicco, CP; Carter, PH gamma-Lactams as glycinamide replacements in cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists. Bioorg Med Chem Lett20:2425-30 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C-C chemokine receptor type 2
Name:C-C chemokine receptor type 2
Synonyms:C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:Enzyme
Mol. Mass.:41932.32
Organism:Homo sapiens (Human)
Description:P41597
Residue:374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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  Blast E-value cutoff:
BDBM50315999
n/a
NameBDBM50315999
Synonyms:CHEMBL1092739 | tert-butyl 2-((S)-1-((1S,2R)-2-(4-(methylthio)benzylamino)cyclohexyl)-2-oxopyrrolidin-3-ylcarbamoyl)-4-(trifluoromethyl)phenylcarbamate
TypeSmall organic molecule
Emp. Form.C31H39F3N4O4S
Mol. Mass.620.726
SMILESCSc1ccc(CN[C@@H]2CCCC[C@@H]2N2CC[C@H](NC(=O)c3cc(ccc3NC(=O)OC(C)(C)C)C(F)(F)F)C2=O)cc1 |r|
Structure
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