Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM50316326 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_627830 (CHEMBL1117207) |
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Ki | 29±n/a nM |
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Citation | Czopek, A; Byrtus, H; Kolaczkowski, M; Pawlowski, M; Dybala, M; Nowak, G; Tatarczynska, E; Wesolowska, A; Chojnacka-Wójcik, E Synthesis and pharmacological evaluation of new 5-(cyclo)alkyl-5-phenyl- and 5-spiroimidazolidine-2,4-dione derivatives. Novel 5-HT1A receptor agonist with potential antidepressant and anxiolytic activity. Eur J Med Chem45:1295-303 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46445.29 |
Organism: | Rattus norvegicus (rat) |
Description: | Binding assays were performed using rat hippocampal membranes. |
Residue: | 422 |
Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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BDBM50316326 |
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n/a |
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Name | BDBM50316326 |
Synonyms: | CHEMBL1098614 | rac-5-Methyl-5-pheny-3-{3-[4-(3-chlorophenyl)piperazin-1-yl]-propyl}-imidazolidine-2,4-dione |
Type | Small organic molecule |
Emp. Form. | C23H27ClN4O2 |
Mol. Mass. | 426.939 |
SMILES | CC1(NC(=O)N(CCCN2CCN(CC2)c2cccc(Cl)c2)C1=O)c1ccccc1 |
Structure |
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