Ki Summary

Reaction Details

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Target

Cyclin-dependent kinase 2/G1/S-specific cyclin-E1

Ligand

BDBM50317174

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_631113 (CHEMBL1103822)

IC50

2950±n/a nM

Citation

Choi, SJ; Lee, JE; Jeong, SY; Im, I; Lee, SD; Lee, EJ; Lee, SK; Kwon, SM; Ahn, SG; Yoon, JH; Han, SY; Kim, JI; Kim, YC 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem53:3696-706 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cyclin-dependent kinase 2/G1/S-specific cyclin-E1

Name:

Cyclin-dependent kinase 2/G1/S-specific cyclin-E1

Synonyms:

Type:

Protein

Mol. Mass.:

n/a

Description:

n/a

Components:

This complex has 2 components.

Component 1

Name:

Cyclin-dependent kinase 2

Synonyms:

Type:

Enzyme Subunit

Mol. Mass.:

33938.17

Organism:

Homo sapiens (Human)

Description:

P24941

Residue:

298

Sequence:

MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

Component 2

Name:

G1/S-specific cyclin-E1

Synonyms:

CCNE | CCNE1 | CCNE1_HUMAN

Type:

Enzyme Subunit

Mol. Mass.:

47073.17

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

410

Sequence:

MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQ
PWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIM
LNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQ
ENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWR
LSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILA
ASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNI
QTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA

BDBM50317174

n/a

Name

BDBM50317174

Synonyms:

(2'Z,3'E)-5-Nitro-5'-methoxy-indirubin-3'-oxime | CHEMBL1087739

Type

Small organic molecule

Emp. Form.

C17H12N4O5

Mol. Mass.

352.301

SMILES

COc1ccc2[nH]c(c(N=[OH+])c2c1)-[c-]1c2cc(ccc2[nH]c1=O)[N+]([O-])=O |(-5.72,-39.64,;-5.72,-41.18,;-4.38,-41.95,;-4.38,-43.49,;-3.05,-44.26,;-1.72,-43.49,;-.24,-43.97,;.67,-42.72,;-.24,-41.46,;.23,-40,;1.74,-39.67,;-1.72,-41.94,;-3.05,-41.18,;2.21,-42.72,;3.11,-41.47,;2.79,-39.97,;3.92,-38.94,;5.4,-39.41,;5.72,-40.91,;4.58,-41.94,;4.58,-43.48,;3.11,-43.96,;2.64,-45.43,;3.59,-37.44,;4.73,-36.4,;2.13,-36.97,)|

Structure