Ki Summary

Reaction Details

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Target

Cyclin-dependent kinase 2/G1/S-specific cyclin-E1

Ligand

BDBM50317169

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_631113 (CHEMBL1103822)

IC50

1.7±n/a nM

Citation

Choi, SJ; Lee, JE; Jeong, SY; Im, I; Lee, SD; Lee, EJ; Lee, SK; Kwon, SM; Ahn, SG; Yoon, JH; Han, SY; Kim, JI; Kim, YC 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem53:3696-706 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cyclin-dependent kinase 2/G1/S-specific cyclin-E1

Name:

Cyclin-dependent kinase 2/G1/S-specific cyclin-E1

Synonyms:

Type:

Protein

Mol. Mass.:

n/a

Description:

n/a

Components:

This complex has 2 components.

Component 1

Name:

Cyclin-dependent kinase 2

Synonyms:

Type:

Enzyme Subunit

Mol. Mass.:

33938.17

Organism:

Homo sapiens (Human)

Description:

P24941

Residue:

298

Sequence:

MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

Component 2

Name:

G1/S-specific cyclin-E1

Synonyms:

CCNE | CCNE1 | CCNE1_HUMAN

Type:

Enzyme Subunit

Mol. Mass.:

47073.17

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

410

Sequence:

MPRERRERDAKERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKIDRTARDQCGSQ
PWDNNAVCADPCSLIPTPDKEDDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIM
LNKEKTYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQ
ENVVKTLLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWR
LSPLTIVSWLNVYMQVAYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILA
ASALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDAHNI
QTHRDSLDLLDKARAKKAMLSEQNRASPLPSGLLTPPQSGKKQSSGPEMA

BDBM50317169

n/a

Name

BDBM50317169

Synonyms:

(2'Z,3'E)-5-Nitro-5'-fluoro-indirubin-3'-oxime | CHEMBL1087073

Type

Small organic molecule

Emp. Form.

C16H9FN4O4

Mol. Mass.

340.2655

SMILES

[O-][N+](=O)c1ccc2[nH]c(=O)[c-](-c3[nH]c4ccc(F)cc4c3N=[OH+])c2c1 |(19.84,4.61,;18.7,3.57,;17.23,4.04,;19.03,2.07,;20.5,1.6,;20.83,.09,;19.69,-.94,;19.69,-2.48,;18.22,-2.96,;17.74,-4.42,;17.32,-1.71,;15.78,-1.71,;14.87,-2.97,;13.39,-2.49,;12.06,-3.26,;10.72,-2.49,;10.73,-.94,;9.39,-.17,;12.05,-.17,;13.39,-.93,;14.87,-.45,;15.34,1.01,;16.85,1.33,;18.22,-.46,;17.9,1.03,)|

Structure