Reaction Details | |||
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Target | Inhibitor of nuclear factor kappa-B kinase subunit beta | ||
Ligand | BDBM50317161 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_631119 (CHEMBL1106491) | ||
IC50 | 10000±n/a nM | ||
Citation | Choi, SJ; Lee, JE; Jeong, SY; Im, I; Lee, SD; Lee, EJ; Lee, SK; Kwon, SM; Ahn, SG; Yoon, JH; Han, SY; Kim, JI; Kim, YC 5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activity. J Med Chem53:3696-706 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Inhibitor of nuclear factor kappa-B kinase subunit beta | |||
Name: | Inhibitor of nuclear factor kappa-B kinase subunit beta | ||
Synonyms: | I-kappa-B Kinase 2 (IKK-beta) | I-kappa-B kinase 2 | I-kappa-B-kinase beta | I-kappa-B-kinase beta (IKKB) | IKBKB | IKK-B | IKK-beta | IKK2 | IKK2/IKK1 | IKKB | IKKB_HUMAN | Inhibitor of NF-kappa-B kinase alpha/beta | Inhibitor of nuclear factor kappa B kinase beta subunit | NFKBIKB | Nuclear factor NF-kappa-B inhibitor kinase beta | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 86554.39 | ||
Organism: | Homo sapiens (Human) | ||
Description: | GST-tagged IKK-2 was expressed in High Five cells and purified. | ||
Residue: | 756 | ||
Sequence: |
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BDBM50317161 | |||
n/a | |||
Name | BDBM50317161 | ||
Synonyms: | (2'Z,3'E)-5-Nitro-5'-hydroxy-indirubin-3'-oxime | CHEMBL1088704 | ||
Type | Small organic molecule | ||
Emp. Form. | C16H10N4O5 | ||
Mol. Mass. | 338.2744 | ||
SMILES | Oc1ccc2[nH]c(c(N=[OH+])c2c1)-[c-]1c2cc(ccc2[nH]c1=O)[N+]([O-])=O |(-8.68,.59,;-7.35,-.18,;-7.35,-1.72,;-6.01,-2.49,;-4.68,-1.72,;-3.21,-2.2,;-2.29,-.95,;-3.21,.31,;-2.73,1.77,;-1.22,2.09,;-4.68,-.17,;-6.02,.59,;-.75,-.95,;.15,.3,;-.18,1.8,;.96,2.83,;2.43,2.36,;2.75,.85,;1.61,-.18,;1.61,-1.72,;.15,-2.19,;-.33,-3.66,;.63,4.33,;1.77,5.37,;-.84,4.8,)| | ||
Structure |