| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cholinesterase |
|---|
| Ligand | BDBM50317197 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_631312 (CHEMBL1105649) |
|---|
| IC50 | 6331±n/a nM |
|---|
| Citation |  Rook, Y; Schmidtke, KU; Gaube, F; Schepmann, D; Wünsch, B; Heilmann, J; Lehmann, J; Winckler, T Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem53:3611-7 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cholinesterase |
|---|
| Name: | Cholinesterase |
|---|
| Synonyms: | BCHE | Butyrylcholinesterase (BuChE) | CHLE_HORSE | Cholinesterase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 65643.35 |
|---|
| Organism: | Equus caballus (Horse) |
|---|
| Description: | P81908 |
|---|
| Residue: | 574 |
|---|
| Sequence: | EEDIIITTKNGKVRGMNLPVLGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSNIWNATK
YANSCYQNTDQSFPGFLGSEMWNPNTELSEDCLYLNVWIPAPKPKNATVMIWIYGGGFQT
GTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLALSENPEAPGNMGLFDQQLALQWVQK
NIAAFGGNPRSVTLFGESAGAASVSLHLLSPRSQPLFTRAILQSGSSNAPWAVTSLYEAR
NRTLTLAKRMGCSRDNETEMIKCLRDKDPQEILLNEVFVVPYDTLLSVNFGPTVDGDFLT
DMPDTLLQLGQFKRTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPR
VSEFGRESILFHYMDWLDDQRAENYREALDDVVGDYNIICPALEFTRKFSELGNDAFFYY
FEHRSTKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEILSRSIMKRWANFAKYGNP
NGTQNNSTRWPVFKSTEQKYLTLNTESPKVYTKLRAQQCRFWTLFFPKVLELTGNIDEAE
REWKAGFHRWNNYMMDWKNQFNDYTSKKESCSDF
|
|
|
|---|
| BDBM50317197 |
|---|
| n/a |
|---|
| Name | BDBM50317197 |
|---|
| Synonyms: | 2-(6-Pyridinium-1-yl-hexyl)-beta-carboline-2-ium dibromide | CHEMBL1097509 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H25N3 |
|---|
| Mol. Mass. | 331.4529 |
|---|
| SMILES | C(CCC[n+]1ccc2c(c1)[nH]c1ccccc21)CC[n+]1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
