Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 2A

Ligand

BDBM50308003

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_631537 (CHEMBL1103902)

11±n/a nM

Citation

Pazini, F; Menegatti, R; Sabino, JR; Andrade, CH; Neves, G; Rates, SM; Noël, F; Fraga, CA; Barreiro, EJ; de Oliveira, V Design of new dopamine D2 receptor ligands: biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581. Bioorg Med Chem Lett20:2888-91 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 2A

Name:

5-hydroxytryptamine receptor 2A

Synonyms:

5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

52852.05

Organism:

Rattus norvegicus (rat)

Description:

Rat cortex membranes 5-HT2A receptors.

Residue:

471

Sequence:

MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV

BDBM50308003

n/a

Name

BDBM50308003

Synonyms:

1-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-4-phenylpiperazine | 1-[(1-(4-Chlorophenyl)-1H-1,2,3-triazol-4-yl)methyl]-4-phenylpiperazine | CHEMBL609043

Type

Small organic molecule

Emp. Form.

C19H20ClN5

Mol. Mass.

353.849

SMILES

Clc1ccc(cc1)-n1cc(CN2CCN(CC2)c2ccccc2)nn1

Structure