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TargetProstaglandin E2 receptor EP2 subtype
LigandBDBM50317903
Substrate/Competitorn/a
Meas. Tech.ChEMBL_630198 (CHEMBL1117301)
Ki>10000±n/a nM
Citation Asada, MObitsu, TKinoshita, ANagase, TYoshida, TYamaura, YTakizawa, HYoshikawa, KSato, KNarita, MNakai, HToda, MTobe, Y 3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 3: Synthesis, metabolic stability, and biological evaluation of optically active analogs. Bioorg Med Chem18:3212-23 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E2 receptor EP2 subtype
Name:Prostaglandin E2 receptor EP2 subtype
Synonyms:PE2R2_MOUSE | PGE receptor, EP2 subtype | Prostaglandin E2 | Prostaglandin E2 receptor EP2 subtype | Prostanoid EP2 receptor | Ptger2 | Ptgerep2
Type:G-protein coupled receptor
Mol. Mass.:40495.26
Organism:Mus musculus (Mouse)
Description:n/a
Residue:362
Sequence:
MDNFLNDSKLMEDCKSRQWLLSGESPAISSVMFSAGVLGNLIALALLARRWRGDTGCSAG
SRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESHACTYFAFTMTFF
SLATMLMLFAMALERYLSIGYPYFYRRHLSRRGGLAVLPVIYGASLLFCSLPLLNYGEYV
QYCPGTWCFIRHGRTAYLQLYATMLLLLIVAVLACNISVILNLIRMHRRSRRSRCGLSGS
SLRGPGSRRRGERTSMAEETDHLILLAIMTITFAICSLPFTIFAYMDETSSLKEKWDLRA
LRFLSVNSIIDPWVFAILRPPVLRLMRSVLCCRTSLRTQEAQQTSCSTQSSASKQTDLCG
QL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50317903
n/a
NameBDBM50317903
Synonyms:3-[4-[(3,5-Difluorophenyl)amino]-2-({[(1R)-1-(3,5-dimethylphenyl)-3-methylbutyl]amino}carbonyl)phenyl]-propanoic acid | CHEMBL1095066
TypeSmall organic molecule
Emp. Form.C29H32F2N2O3
Mol. Mass.494.5728
SMILESCC(C)C[C@@H](NC(=O)c1cc(Nc2cc(F)cc(F)c2)ccc1CCC(O)=O)c1cc(C)cc(C)c1 |r|
Structure
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