| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP3 subtype |
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| Ligand | BDBM50317908 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_630201 (CHEMBL1117304) |
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| IC50 | 1.9±n/a nM |
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| Citation |  Asada, M; Obitsu, T; Kinoshita, A; Nagase, T; Yoshida, T; Yamaura, Y; Takizawa, H; Yoshikawa, K; Sato, K; Narita, M; Nakai, H; Toda, M; Tobe, Y 3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 3: Synthesis, metabolic stability, and biological evaluation of optically active analogs. Bioorg Med Chem18:3212-23 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E2 receptor EP3 subtype |
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| Name: | Prostaglandin E2 receptor EP3 subtype |
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| Synonyms: | PE2R3_MOUSE | PGE receptor, EP3 isoform alpha | Prostaglandin E2 receptor EP3 isoform alpha | Prostaglandin E3 | Prostanoid EP3 receptor | Ptger3 | Ptgerep3 |
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| Type: | G-protein coupled receptor |
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| Mol. Mass.: | 40092.50 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | n/a |
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| Residue: | 365 |
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| Sequence: | MASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESK
RKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLS
SLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWP
GTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKA
AVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKE
CNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWS
DQLER
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| BDBM50317908 |
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| n/a |
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| Name | BDBM50317908 |
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| Synonyms: | 3-{2-({[(1R)-1-(3,5-Dimethylphenyl)-3-methylbutyl]-amino}carbonyl)-4-[(2-methylphenoxy)methyl]phenyl}-propanoic acid | CHEMBL1094157 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H37NO4 |
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| Mol. Mass. | 487.6298 |
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| SMILES | CC(C)C[C@@H](NC(=O)c1cc(COc2ccccc2C)ccc1CCC(O)=O)c1cc(C)cc(C)c1 |r| |
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| Structure | 
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