| Reaction Details |
|---|
 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
|---|
| Ligand | BDBM50318014 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_630934 (CHEMBL1116533) |
|---|
| IC50 | 8±n/a nM |
|---|
| Citation |  Chen, X; Pierce, B; Naing, W; Grapperhaus, ML; Phillion, DP Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist. Bioorg Med Chem Lett20:3107-11 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| P2X purinoceptor 7 |
|---|
| Name: | P2X purinoceptor 7 |
|---|
| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68602.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q99572 |
|---|
| Residue: | 595 |
|---|
| Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
|
|
|
|---|
| BDBM50318014 |
|---|
| n/a |
|---|
| Name | BDBM50318014 |
|---|
| Synonyms: | 2-chloro-N-((1-hydroxycycloheptyl)methyl)-5-(5-methylpyrimidin-2-yl)benzamide | CHEMBL1094738 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H24ClN3O2 |
|---|
| Mol. Mass. | 373.876 |
|---|
| SMILES | Cc1cnc(nc1)-c1ccc(Cl)c(c1)C(=O)NCC1(O)CCCCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
