Reaction Details |
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Target | P2X purinoceptor 7 |
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Ligand | BDBM50318019 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_630934 (CHEMBL1116533) |
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IC50 | 46±n/a nM |
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Citation | Chen, X; Pierce, B; Naing, W; Grapperhaus, ML; Phillion, DP Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist. Bioorg Med Chem Lett20:3107-11 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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P2X purinoceptor 7 |
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Name: | P2X purinoceptor 7 |
Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
Type: | Protein |
Mol. Mass.: | 68602.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99572 |
Residue: | 595 |
Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
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BDBM50318019 |
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n/a |
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Name | BDBM50318019 |
Synonyms: | 2-chloro-N-((4,4-difluoro-1-hydroxycycloheptyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide | CHEMBL1096083 |
Type | Small organic molecule |
Emp. Form. | C19H19ClF3N3O2 |
Mol. Mass. | 413.821 |
SMILES | OC1(CNC(=O)c2cc(ccc2Cl)-c2ncc(F)cn2)CCCC(F)(F)CC1 |
Structure |
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