Reaction Details |
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Target | Bcl-2-like protein 1 |
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Ligand | BDBM50318200 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_628973 (CHEMBL1120823) |
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IC50 | 5300±n/a nM |
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Citation | Feng, Y; Ding, X; Chen, T; Chen, L; Liu, F; Jia, X; Luo, X; Shen, X; Chen, K; Jiang, H; Wang, H; Liu, H; Liu, D Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors. J Med Chem53:3465-79 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bcl-2-like protein 1 |
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Name: | Bcl-2-like protein 1 |
Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
Type: | Mitochondrion membrane; Single-pass membrane protein |
Mol. Mass.: | 26039.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 233 |
Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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BDBM50318200 |
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n/a |
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Name | BDBM50318200 |
Synonyms: | (Z)-3-(5-((7-(2-Methoxyphenyl)-9-oxo-5H-benzo[h]thiazolo[2,3-b]-quinazolin-10(6H,7H,9H)-ylidene)methyl)furan-2-yl)benzoic Acid | CHEMBL1098323 |
Type | Small organic molecule |
Emp. Form. | C33H24N2O5S |
Mol. Mass. | 560.619 |
SMILES | COc1ccccc1C1C2=C(N=c3s\c(=C/c4ccc(o4)-c4cccc(c4)C(O)=O)c(=O)n13)c1ccccc1CC2 |c:10,t:12| |
Structure |
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