| Reaction Details |
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 | Report a problem with these data |
| Target | 17-beta-hydroxysteroid dehydrogenase type 2 |
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| Ligand | BDBM50318417 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_630247 (CHEMBL1106456) |
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| IC50 | 2970±n/a nM |
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| Citation |  Oster, A; Klein, T; Werth, R; Kruchten, P; Bey, E; Negri, M; Marchais-Oberwinkler, S; Frotscher, M; Hartmann, RW Novel estrone mimetics with high 17beta-HSD1 inhibitory activity. Bioorg Med Chem18:3494-505 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 17-beta-hydroxysteroid dehydrogenase type 2 |
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| Name: | 17-beta-hydroxysteroid dehydrogenase type 2 |
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| Synonyms: | 17-beta-Hydroxysteroid Dehydrogenase 2 (17-beta-HSD2) | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB2_HUMAN | EDH17B2 | Estradiol 17-beta-dehydrogenase 2 | Estradiol 17-beta-dehydrogenase 2 (17beta-HSD2) | HSD17B2 | Microsomal 17-beta-hydroxysteroid dehydrogenas | SDR9C2 | Testosterone 17-beta-dehydrogenase |
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| Type: | Oxidoreductase; single-pass type II membrane protein |
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| Mol. Mass.: | 42795.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Enzyme was partially purified from human placenta. |
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| Residue: | 387 |
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| Sequence: | MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLIL
FSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPG
AEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELL
LMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVT
MFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYI
LAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYD
YFAKRHFGQDKPMPRALRMPNYKKKAT
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| BDBM50318417 |
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| n/a |
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| Name | BDBM50318417 |
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| Synonyms: | 4'-(6-Methoxypyridin-3-yl)biphenyl-3-ol | CHEMBL1097417 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H15NO2 |
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| Mol. Mass. | 277.3172 |
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| SMILES | COc1ccc(cn1)-c1ccc(cc1)-c1cccc(O)c1 |
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| Structure | 
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