Reaction Details |
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Target | Cyclin-dependent kinase 7 |
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Ligand | BDBM50229973 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_634457 (CHEMBL1119483) |
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Ki | 70±n/a nM |
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Citation | Wang, S; Midgley, CA; Scaërou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors. J Med Chem53:4367-78 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 7 |
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Name: | Cyclin-dependent kinase 7 |
Synonyms: | 39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit |
Type: | Enzyme Subunit |
Mol. Mass.: | 39047.01 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 346 |
Sequence: | MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
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BDBM50229973 |
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n/a |
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Name | BDBM50229973 |
Synonyms: | (4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(3-nitrophenyl)amine | 4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)thiazol-2-amine | CHEMBL298445 | [4-(2-AMINO-4-METHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-(3-NITRO-PHENYL)-AMINE |
Type | Small organic molecule |
Emp. Form. | C14H12N6O2S |
Mol. Mass. | 328.349 |
SMILES | Cc1nc(N)sc1-c1ccnc(Nc2cccc(c2)[N+]([O-])=O)n1 |
Structure |
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