| Reaction Details |
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 | Report a problem with these data |
| Target | Exportin-1 |
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| Ligand | BDBM50240512 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_635789 (CHEMBL1120677) |
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| IC50 | 1600±n/a nM |
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| Citation |  Tamura, S; Fujitani, T; Kaneko, M; Murakami, N Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus. Bioorg Med Chem Lett20:3717-20 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Exportin-1 |
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| Name: | Exportin-1 |
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| Synonyms: | CRM1 | XPO1 | XPO1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 123374.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_635789 |
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| Residue: | 1071 |
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| Sequence: | MPAIMTMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAW
TRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGIKKYVVGLIIKTSSDPTCV
EKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLLSEEVFD
FSSGQITQVKSKHLKDSMCNEFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGY
IFETKLISTLIYKFLNVPMFRNVSLKCLTEIAGVSVSQYEEQFVTLFTLTMMQLKQMLPL
NTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHDQLIEKRLNLRETLMEALHYMLLVSEV
EETEIFKICLEYWNHLAAELYRESPFSTSASPLLSGSQHFDVPPRRQLYLPMLFKVRLLM
VSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDTERIMTEKL
HNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAII
ASNIMYIVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFV
QVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTVQEHLIEKYMLL
PNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNV
YKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPL
LDAVLIDYQRNVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEE
YPEHRTNFFLLLQAVNSHCFPAFLAIPPTQFKLVLDSIIWAFKHTMRNVADTGLQILFTL
LQNVAQEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKIST
SLNPGNPVNNQIFLQEYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLV
QIKEFAGEDTSDLFLEEREIALRQADEEKHKRQMSVPGIFNPHEIPEEMCD
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| BDBM50240512 |
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| n/a |
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| Name | BDBM50240512 |
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| Synonyms: | 7-Methoxy-8-(3-methyl-but-2-enyl)-chromen-2-one | CHEMBL52229 | Osthol | osthole |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16O3 |
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| Mol. Mass. | 244.2857 |
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| SMILES | [#6]-[#8]-c1ccc2ccc(=O)oc2c1-[#6]\[#6]=[#6](\[#6])-[#6] |
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| Structure | 
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