| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM50118044 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_636763 (CHEMBL1167052) |
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| IC50 | 390±n/a nM |
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| Citation |  Abu Khalaf, R; Abu Sheikha, G; Bustanji, Y; Taha, MO Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic exploration. Eur J Med Chem45:1598-617 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_RABIT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 54513.38 |
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| Organism: | Oryctolagus cuniculus |
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| Description: | ChEMBL_1504757 |
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| Residue: | 497 |
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| Sequence: | ACPKGASYEAGIVCRITKPALLVLNQETAKVVQTAFQRAGYPDVSGERAVMLLGRVKYGL
HNLQISHLSIASSQVELVDAKTIDVAIQNVSVVFKGTLNYSYTSAWGLGINQSVDFEIDS
AIDLQINTELTCDAGSVRTNAPDCYLAFHKLLLHLQGEREPGWLKQLFTNFISFTLKLIL
KRQVCNEINTISNIMADFVQTRAASILSDGDIGVDISVTGAPVITATYLESHHKGHFTHK
NVSEAFPLRAFPPGLLGDSRMLYFWFSDQVLNSLARAAFQEGRLVLSLTGDEFKKVLETQ
GFDTNQEIFQELSRGLPTGQAQVAVHCLKVPKISCQNRGVVVSSSVAVTFRFPRPDGREA
VAYRFEEDIITTVQASYSQKKLFLHLLDFQCVPASGRAGSSANLSVALRTEAKAVSNLTE
SRSESLQSSLRSLIATVGIPEVMSRLEVAFTALMNSKGLDLFEIINPEIITLDGCLLLQM
DFGFPKHLLVDFLQSLS
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| BDBM50118044 |
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| n/a |
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| Name | BDBM50118044 |
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| Synonyms: | 1,1,1-Trifluoro-3-[(3-phenoxy-phenyl)-(3-trifluoromethylsulfanyl-benzyl)-amino]-propan-2-ol | 1,1,1-trifluoro-3-((3-phenoxyphenyl)(3-(trifluoromethylthio)benzyl)amino)propan-2-ol | CHEMBL129412 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H19F6NO2S |
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| Mol. Mass. | 487.458 |
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| SMILES | OC(CN(Cc1cccc(SC(F)(F)F)c1)c1cccc(Oc2ccccc2)c1)C(F)(F)F |
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| Structure | 
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