Reaction Details |
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Target | RAC-alpha serine/threonine-protein kinase |
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Ligand | BDBM24855 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_643086 (CHEMBL1176552) |
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IC50 | 2±n/a nM |
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Citation | Freeman-Cook, KD; Autry, C; Borzillo, G; Gordon, D; Barbacci-Tobin, E; Bernardo, V; Briere, D; Clark, T; Corbett, M; Jakubczak, J; Kakar, S; Knauth, E; Lippa, B; Luzzio, MJ; Mansour, M; Martinelli, G; Marx, M; Nelson, K; Pandit, J; Rajamohan, F; Robinson, S; Subramanyam, C; Wei, L; Wythes, M; Morris, J Design of selective, ATP-competitive inhibitors of Akt. J Med Chem53:4615-22 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RAC-alpha serine/threonine-protein kinase |
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Name: | RAC-alpha serine/threonine-protein kinase |
Synonyms: | AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT) |
Type: | Enzyme |
Mol. Mass.: | 55681.25 |
Organism: | Homo sapiens (Human) |
Description: | P31749 |
Residue: | 480 |
Sequence: | MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
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BDBM24855 |
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n/a |
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Name | BDBM24855 |
Synonyms: | 4-{1,2-dihydrospiro[indole-3,4'-piperidine]}-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile | pyrrolopyrimidine, 13j |
Type | Small organic molecule |
Emp. Form. | C19H18N6 |
Mol. Mass. | 330.3864 |
SMILES | N#Cc1c[nH]c2ncnc(N3CC4(CCNCC4)c4ccccc34)c12 |
Structure |
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