| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor |
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| Ligand | BDBM50303803 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_648798 (CHEMBL1220637) |
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| Ki | 0.300000±n/a nM |
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| Citation |  Dennis, MK; Burai, R; Ramesh, C; Petrie, WK; Alcon, SN; Nayak, TK; Bologa, CG; Leitao, A; Brailoiu, E; Deliu, E; Dun, NJ; Sklar, LA; Hathaway, HJ; Arterburn, JB; Oprea, TI; Prossnitz, ER In vivo effects of a GPR30 antagonist. Nat Chem Biol5:421-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor |
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| Name: | Estrogen receptor |
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| Synonyms: | ESR1_MOUSE | Esr | Esr1 | Estr | Estra | Estrogen receptor alpha | Nr3a1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66969.87 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_648798 |
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| Residue: | 599 |
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| Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKMPMERALGEVYVDNSKPTVFNYPEGAAY
EFNAAAAAAAAASAPVYGQSGIAYGPGSEAAAFSANSLGAFPQLNSVSPSPLMLLHPPPQ
LSPFLHPHGQQVPYYLENEPSAYAVRDTGPPAFYRSNSDNRRQNGRERLSSSNEKGNMIM
ESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKS
CQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDLEGRNEMGASGDMRAANLWPSPL
VIKHTKKNSPALSLTADQMVSALLDAEPPMIYSEYDPSRPFSEASMMGLLTNLADRELVH
MINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGK
CVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIH
RVLDKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHIRHMSNKGMEHLYNMKCKNVVPL
YDLLLEMLDAHRLHAPASRMGVPPEEPSQTQLATTSSTSAHSLQTYYIPPEAEGFPNTI
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| BDBM50303803 |
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| n/a |
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| Name | BDBM50303803 |
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| Synonyms: | 1-((3aS,4R,9bR)-4-(6-bromobenzo[d][1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl)ethanone | CHEMBL569766 | cid_3136849 | cid_5322399 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18BrNO3 |
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| Mol. Mass. | 412.277 |
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| SMILES | CC(=O)c1ccc2N[C@H]([C@H]3CC=C[C@H]3c2c1)c1cc2OCOc2cc1Br |r,c:11| |
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| Structure | 
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