| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aurora kinase A |
|---|
| Ligand | BDBM50324250 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_650022 (CHEMBL1219720) |
|---|
| IC50 | 362±n/a nM |
|---|
| Citation |  Chiang, CC; Lin, YH; Lin, SF; Lai, CL; Liu, C; Wei, WY; Yang, SC; Wang, RW; Teng, LW; Chuang, SH; Chang, JM; Yuan, TT; Lee, YS; Chen, P; Chi, WK; Yang, JY; Huang, HJ; Liao, CB; Huang, JJ Discovery of pyrrole-indoline-2-ones as Aurora kinase inhibitors with a different inhibition profile. J Med Chem53:5929-41 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aurora kinase A |
|---|
| Name: | Aurora kinase A |
|---|
| Synonyms: | AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 45830.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O14965 |
|---|
| Residue: | 403 |
|---|
| Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
|
|
|
|---|
| BDBM50324250 |
|---|
| n/a |
|---|
| Name | BDBM50324250 |
|---|
| Synonyms: | (Z)-3-{4-Acetyl-2-[(5-fluoro-2-oxoindolin-3-ylidene)methyl]-5-methyl-1H-pyrrol-3-yl}propanoic Acid | CHEMBL1214853 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H17FN2O4 |
|---|
| Mol. Mass. | 356.3477 |
|---|
| SMILES | CC(=O)c1c(C)[nH]c(C=C2C(=O)Nc3ccc(F)cc23)c1CCC(O)=O |w:8.7| |
|---|
| Structure | 
|
|---|
Search and Browse
