| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2A |
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| Ligand | BDBM50324542 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_649427 (CHEMBL1219125) |
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| Ki | 2.7±n/a nM |
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| Citation |  Xiong, Y; Ullman, B; Choi, JS; Cherrier, M; Strah-Pleynet, S; Decaire, M; Dosa, PI; Feichtinger, K; Teegarden, BR; Frazer, JM; Yoon, WH; Shan, Y; Whelan, K; Hauser, EK; Grottick, AJ; Semple, G; Al-Shamma, H Synthesis and in vivo evaluation of phenethylpiperazine amides: selective 5-hydroxytryptamine(2A) receptor antagonists for the treatment of insomnia. J Med Chem53:5696-706 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 2A |
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| Name: | 5-hydroxytryptamine receptor 2A |
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| Synonyms: | 5-HTR2A | 5HT2A_CANLF | HTR2A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52384.55 |
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| Organism: | Canis familiaris |
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| Description: | ChEMBL_1361183 |
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| Residue: | 470 |
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| Sequence: | MDVLFEDNAPLSPTTSSLMPSNGDPRLYGNDLNAGDANTSDAFNWTVDAENRTNLSCEGC
LSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDPGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDIIGAL
LNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKS
SQLQMGQKKNSKKDAKSTDNDYSMVALGKQHSEDAPTDNINTVNEKVSCV
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| BDBM50324542 |
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| n/a |
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| Name | BDBM50324542 |
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| Synonyms: | 2-[4-(4-Chloro-1-methyl-1H-pyrazole-3-carbonyl)piperazin-1-yl]-1-(4-fluorophenyl)ethanone | CHEMBL1214946 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18ClFN4O2 |
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| Mol. Mass. | 364.802 |
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| SMILES | Cn1cc(Cl)c(n1)C(=O)N1CCN(CC(=O)c2ccc(F)cc2)CC1 |
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| Structure | 
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