| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM50324699 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_650626 (CHEMBL1225185) |
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| Ki | 80±n/a nM |
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| Citation |  Volgraf, M; Lumb, JP; Brastianos, HC; Carr, G; Chung, MK; Münzel, M; Mauk, AG; Andersen, RJ; Trauner, D Biomimetic synthesis of the IDO inhibitors exiguamine A and B. Nat Chem Biol4:535-7 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45330.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14902 |
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| Residue: | 403 |
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| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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| BDBM50324699 |
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| n/a |
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| Name | BDBM50324699 |
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| Synonyms: | CHEMBL1221473 | Seco-exiguamine |
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| Type | Small organic molecule |
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| Emp. Form. | C25H29N5O6 |
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| Mol. Mass. | 495.5277 |
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| SMILES | CN(C)CCc1ccc(O)c(O)c1C1=C(c2c(O)n(C)c(=O)n2C)C(=O)c2c(CCN)c[nH]c2C1=O |c:14| |
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| Structure | 
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