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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cystic fibrosis transmembrane conductance regulator | ||
| Ligand | BDBM50416576 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_651185 (CHEMBL1227950) | ||
| IC50 | 800±n/a nM | ||
| Citation |  Tradtrantip, L; Sonawane, ND; Namkung, W; Verkman, AS Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. J Med Chem52:6447-55 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cystic fibrosis transmembrane conductance regulator | |||
| Name: | Cystic fibrosis transmembrane conductance regulator | ||
| Synonyms: | ABCC7 | ATP-binding cassette sub-family C member 7 | CFTR | CFTR_HUMAN | Channel conductance-controlling ATPase | cAMP-dependent chloride channel | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 168171.30 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | gi_90421313 | ||
| Residue: | 1480 | ||
| Sequence: |
| ||
| BDBM50416576 | |||
| n/a | |||
| Name | BDBM50416576 | ||
| Synonyms: | CHEMBL1222176 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H24N4O3 | ||
| Mol. Mass. | 452.5045 | ||
| SMILES | Cc1ccc(o1)C1Nc2ccccc2-n2c1c1n(C)c(=O)n(C)c(=O)c1c2-c1ccccc1C |(18.88,.23,;20.34,.7,;20.83,2.16,;22.37,2.14,;22.84,.67,;21.58,-.22,;24.29,.18,;24.3,-1.36,;25.63,-2.12,;25.63,-3.66,;26.97,-4.43,;28.3,-3.66,;28.3,-2.11,;26.96,-1.34,;26.96,.18,;25.62,.95,;25.94,2.46,;25.02,3.69,;23.49,3.52,;25.64,5.11,;24.73,6.35,;27.18,5.28,;27.8,6.69,;28.09,4.04,;29.62,4.21,;27.47,2.63,;28.1,1.22,;29.43,.44,;30.76,1.21,;32.09,.44,;32.09,-1.11,;30.75,-1.88,;29.42,-1.1,;29.01,-2.58,)| | ||
| Structure | 
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