| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Caspase-1 |
|---|
| Ligand | BDBM50324952 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_651546 (CHEMBL1227798) |
|---|
| Ki | 13.4±n/a nM |
|---|
| Citation |  Galatsis, P; Caprathe, B; Gilmore, J; Thomas, A; Linn, K; Sheehan, S; Harter, W; Kostlan, C; Lunney, E; Stankovic, C; Rubin, J; Brady, K; Allen, H; Talanian, R Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1). Bioorg Med Chem Lett20:5184-90 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Caspase-1 |
|---|
| Name: | Caspase-1 |
|---|
| Synonyms: | CASP1_MOUSE | Casp1 | Il1bc |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 45636.44 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_651546 |
|---|
| Residue: | 402 |
|---|
| Sequence: | MADKILRAKRKQFINSVSIGTINGLLDELLEKRVLNQEEMDKIKLANITAMDKARDLCDH
VSKKGPQASQIFITYICNEDCYLAGILELQSAPSAETFVATEDSKGGHPSSSETKEEQNK
EDGTFPGLTGTLKFCPLEKAQKLWKENPSEIYPIMNTTTRTRLALIICNTEFQHLSPRVG
AQVDLREMKLLLEDLGYTVKVKENLTALEMVKEVKEFAACPEHKTSDSTFLVFMSHGIQE
GICGTTYSNEVSDILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRGEKQGVVLLKDSVRD
SEEDFLTDAIFEDDGIKKAHIEKDFIAFCSSTPDNVSWRHPVRGSLFIESLIKHMKEYAW
SCDLEDIFRKVRFSFEQPEFRLQMPTADRVTLTKRFYLFPGH
|
|
|
|---|
| BDBM50324952 |
|---|
| n/a |
|---|
| Name | BDBM50324952 |
|---|
| Synonyms: | (R)-2-((S)-2-isopropyl-4-(2-(2-methyl-1H-indol-3-yl)ethylamino)-4-oxobutanamido)-3-oxopropanoic acid | CHEMBL1221643 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H29N3O5 |
|---|
| Mol. Mass. | 415.4828 |
|---|
| SMILES | CC(C)[C@H](CC(=O)NCCc1c(C)[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
