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TargetCytochrome P450 17A1
LigandBDBM50188092
Substrate/Competitorn/a
Meas. Tech.ChEMBL_652121
IC50 730±n/a nM
Citation Owen CPShahid ILee WYAhmed S Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17alpha-hydroxylase/17,20-lyase (P45017alpha) derived from rat testicular microsomes. Bioorg Med Chem Lett 20:5345-8 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 17A1
Name:Cytochrome P450 17A1
Synonyms:Cytochrome P450 17,20 lyase | Cytochrome P450-C17 | Steroid 17-alpha-hydroxylase/17,20 lyase
Type:Enzyme
Mol. Mass.:57255.68
Organism:Rattus norvegicus (Rat)
Description:P11715
Residue:507
Sequence:
MWELVGLLLLILAYFFWVKSKTPGAKLPRSLPSLPLVGSLPFLPRRGHMHVNFFKLQEKY
GPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKGVAFADAGSS
WHLHRKLVFSTFSLFKDGQKLEKLICQEAKSLCDMMLAHDKESIDLSTPIFMSVTNIICA
ICFNISYEKNDPKLTAIKTFTEGIVDATGDRNLVDIFPWLTIFPNKGLEVIKGYAKVRNE
VLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDVFSDRHILATVGDIFG
AGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFNDRSHLLMLEATIREVL
RIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEWDQPDQFMPERFLDPT
GSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPK
VVFLIDPFKVKITVRQAWMDAQAEVST
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  Blast E-value cutoff:
BDBM50188092
n/a
NameBDBM50188092
Synonyms:1-(4-iodobenzyl)-1H-imidazole | 4-iodobenzyl imidazole | CHEMBL427399
TypeSmall organic molecule
Emp. Form.C10H9IN2
Mol. Mass.284.0963
SMILESIc1ccc(Cn2ccnc2)cc1
Structure
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